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- Apr 16, 2026
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What is retatrutide?
retatrutide is a "Triple g" investigational weight loss drug in its later trialing stage, being developed by Eli Lilly. (The people who made zepbound/mounjaro)
ELI5: it's Eli Lillys end result when they keep adding shit onto ozempic and hope for the best. (And it's worked amazingly so far)
How does retatrutide work? retatrutide works by targeting 3 receptors: GLP-1, GIP & glucagon. These receptors all work together to provide a synergistic combination resulting in superior weightloss to any drug on the market.
Now, what do the receptors actually do?
-Well, glp-1: GLP-1
(Glucagon-like peptide-1)
Works by doing the following:
1. Slows digestion. It slows down the emptying of the gut to keep you feeling fuller, for longer.
2. Sends signals to your brain that are responsible for appetite; reducing appetite.
3. Stimulates insulin production; increases insulin when blood sugar is high, and lowers blood sugar via reducing glucose.
This is ideal since 30–40% of obese adults* have prediabetes (insulin resistance)
-GIP (glucose-dependent insulinotropic polypeptide)
1. Pretty much the same mechanisms as GLP-1 but by targeting different areas to get the effects. Also has slight effects on gastric acid secretetion
2. Some extras: regulates lipid and glucose metabolism in tissues such as the liver, can promote slight bone mineral density benefits, helps with GI effects.
-Glucagon Receptor:
1. Via binding to it's receptor, glucagon increases energy expenditure, making you burn more calories.
2. increases lipid metabolism (Using fat as energy)
(I'd add some more but honestly, nothing relevant i thought needed adding)
__________________________________________________________________________________________________________________________________________
The dosing
Typically, dosing of retatrutide is something many get wrong, and unfortunately pay the price. Typically by pure misery for a week or more. I cannot stress it enough when it comes to any GLP-1 medication; do not be impatient with dosing. if you think it's a good idea to start at anything over 2mg, you're retarded. And your toilet will suffer just as you will.
The most common retatrutide dosingwould go something like this:
(This would be for 25-30%+ bf individuals)
Weeks 1-2: 0.5mg
Weeks 2-4: 1mg
Weeks 4-6: 2mg
weeks 6-8: 4mg
weeks 8-10: 6mg
weeks 10-12: 7mg
weeks 12-14: 8mg (maintenance)
Note: this isn't a one-size-fits-all dosing schedule — individual response to retatrutide may vary. Use this as only a reference; once you've found a dose that works, stay on it as long as it remains effective.
Dosing higher than 8mg is only necessary if a 8mg maintenance dose starts to wear off — escalate by 1-2mg every few weeks if the aforementioned occurs.
If you've gotten to 12mg & still haven't reached your goals, reduce the retatrutide dosage to 6mg and introduce 'cagrilintide'
If you're just looking for a slight cutting aid, escalate like i said & stop at 4mg. Why you may ask? well, the glucagon receptor only seems to kick in at dosages 4mg and up. Which is responsible for increased energy expenditure and lipids.
______________________________________________________________________________________________________________________________________________________________________
Side effects
The typical GI side effects of GLP-1 based medications; nausea, vomiting, diarrhea, and constipation. Other side effects may include: headaches, increased skin-sensitivity, fatigue, and increased heart rate. Though, most of these can be avoided by basic electrolyte & vitamin supplementation.
If you experience anything serious, stop injecting and go to the doctors. And be honest; no-one can help you if you're not honest.
How to not feel like shit, and riskserious long-term complications.⬇
Since retatrutide reduces food intake significantly, you'll have to sufficiently supplement everything you'll be missing;
take a good multi-vitamin & electrolytesupplement.
Here are some i recommend ⬇
www.pipingrock.com
But this won't fully compensate for the reduced food intake. So, track your calories & macros carefully. Rule of thumb is: try to not dip below 1200 calories a day.
retatrutide is a "Triple g" investigational weight loss drug in its later trialing stage, being developed by Eli Lilly. (The people who made zepbound/mounjaro)
ELI5: it's Eli Lillys end result when they keep adding shit onto ozempic and hope for the best. (And it's worked amazingly so far)
How does retatrutide work? retatrutide works by targeting 3 receptors: GLP-1, GIP & glucagon. These receptors all work together to provide a synergistic combination resulting in superior weightloss to any drug on the market.
Now, what do the receptors actually do?
-Well, glp-1: GLP-1
(Glucagon-like peptide-1)
Works by doing the following:
1. Slows digestion. It slows down the emptying of the gut to keep you feeling fuller, for longer.
2. Sends signals to your brain that are responsible for appetite; reducing appetite.
3. Stimulates insulin production; increases insulin when blood sugar is high, and lowers blood sugar via reducing glucose.
This is ideal since 30–40% of obese adults* have prediabetes (insulin resistance)
-GIP (glucose-dependent insulinotropic polypeptide)
1. Pretty much the same mechanisms as GLP-1 but by targeting different areas to get the effects. Also has slight effects on gastric acid secretetion
2. Some extras: regulates lipid and glucose metabolism in tissues such as the liver, can promote slight bone mineral density benefits, helps with GI effects.
-Glucagon Receptor:
1. Via binding to it's receptor, glucagon increases energy expenditure, making you burn more calories.
2. increases lipid metabolism (Using fat as energy)
(I'd add some more but honestly, nothing relevant i thought needed adding)
__________________________________________________________________________________________________________________________________________
The dosing
Typically, dosing of retatrutide is something many get wrong, and unfortunately pay the price. Typically by pure misery for a week or more. I cannot stress it enough when it comes to any GLP-1 medication; do not be impatient with dosing. if you think it's a good idea to start at anything over 2mg, you're retarded. And your toilet will suffer just as you will.
The most common retatrutide dosingwould go something like this:
(This would be for 25-30%+ bf individuals)
Weeks 1-2: 0.5mg
Weeks 2-4: 1mg
Weeks 4-6: 2mg
weeks 6-8: 4mg
weeks 8-10: 6mg
weeks 10-12: 7mg
weeks 12-14: 8mg (maintenance)
Note: this isn't a one-size-fits-all dosing schedule — individual response to retatrutide may vary. Use this as only a reference; once you've found a dose that works, stay on it as long as it remains effective.
Dosing higher than 8mg is only necessary if a 8mg maintenance dose starts to wear off — escalate by 1-2mg every few weeks if the aforementioned occurs.
If you've gotten to 12mg & still haven't reached your goals, reduce the retatrutide dosage to 6mg and introduce 'cagrilintide'
If you're just looking for a slight cutting aid, escalate like i said & stop at 4mg. Why you may ask? well, the glucagon receptor only seems to kick in at dosages 4mg and up. Which is responsible for increased energy expenditure and lipids.
______________________________________________________________________________________________________________________________________________________________________
Side effects
The typical GI side effects of GLP-1 based medications; nausea, vomiting, diarrhea, and constipation. Other side effects may include: headaches, increased skin-sensitivity, fatigue, and increased heart rate. Though, most of these can be avoided by basic electrolyte & vitamin supplementation.
If you experience anything serious, stop injecting and go to the doctors. And be honest; no-one can help you if you're not honest.
How to not feel like shit, and riskserious long-term complications.⬇
Since retatrutide reduces food intake significantly, you'll have to sufficiently supplement everything you'll be missing;
take a good multi-vitamin & electrolytesupplement.
Here are some i recommend ⬇
Elektrolyte Hydratation, 180 Tabletten
Bleiben Sie hydriert mit den Piping Rock Elektrolyte Hydration†Tabletten, die fünf wichtige Elektrolyte in einer zuckerfreien, geschmacklosen Formel enthalten. Nehmen Sie sie überallhin mit!
www.pipingrock.com
But this won't fully compensate for the reduced food intake. So, track your calories & macros carefully. Rule of thumb is: try to not dip below 1200 calories a day.
